ANALYSIS OF OPTICIN BINDING TO COLLAGEN FIBRILS IDENTIFIES A SINGLE BINDING SITE IN THE GAP REGION AND A HIGH SPECIFICITY TOWARDS THIN HETEROTYPIC FIBRILS CONTAINING COLLAGENS II, AND XI OR V/XI.

Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI.

Opticin is a class III member of the extracellular matrix small leucine-rich repeat protein/proteoglycan (SLRP) family found in vitreous humour and cartilage.It was first identified associated with the surface of vitreous collagen fibrils and several other SLRPs are also known to bind collagen fibrils and it some cases alter fibril morphology.The p

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Bayesian feedback in the framework of ecological sciences

In ecological studies, it is not uncommon to encounter scenarios where the same phenomenon (e.g., species occurrence, species abundance) is observed using two different types of samplers.For example, species data can be collected from scientific sampling with a completely random sample pattern, but also from opportunistic sampling (e.g., whale watc

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